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Gum Disease Linked to Alzheimer’s Disease by New Research

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A simple blood test could predict if a patient will develop Alzheimer's disease up to 16 years before symptoms begin a new study finds

"Drugs targeting the bacteria's toxic proteins have so far only shown benefit in mice, yet with no new dementia treatments in over 15 years it's important that we test as many approaches as possible to tackle diseases like Alzheimer's", he said in a statement.

Researchers at Shiley-Marcos Alzheimer's Disease Research Center, part of the University of California San Diego School of Medicine, found that autopsies of patients diagnosed with AD when they were alive-and confirmed by autopsy-indicate several cognitive issues symptomatic of the condition are less noticeable in living Latino patients.

Following this, scientists tested drugs in mice aimed at blocking the toxic proteins and found they were able to halt degeneration in the brain.

Other research has looked at whether various bacterial, viral, or fungal infections may play a role in Alzheimer's, but there is now not enough evidence to say. Now, a new research effort is pointing to a link between Alzheimer's and something you might not expect: gum disease.

It's possible that news of the possible link will lead to people spending more time on their dental health than they now do, though: One study found less than one third of Americans floss daily.

In separate experiments with mice, oral infection with the pathogen led to brain colonisation by the bacteria, together with increased production of amyloid beta (Aβ), the sticky proteins commonly associated with Alzheimer's.

Their NFL protein levels were measured through a blood test, brain images, and cognitive tests every 2.5 years, over the last seven.

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To study whether the spread of tau tangles is affected by sleep, the researchers seeded the hippocampi of mice with tiny clumps of tau and then kept the animals awake for long periods each day. Although it is not known whether getting adequate sleep will protect against AD, it won't hurt and this along with other data suggests it may even help to delay disease process if it has begun, says Holtzman.

According to a new study, bleeding gums and sensitive teeth are not only painful and annoying, but they are also having a never-before-seen connection with the Alzheimer's Disease. What the team discovered was reported January 24 in the journal Science, in an article titled, "The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans".

"The impact of infectious agents previously associated with the development and progression of Alzheimer's disease, but a causal relationship is still inconclusive". They tested the tissue samples for the presence of 2 protein fragments produced by P. gingivalis bacteria, called gingipains to see if people with Alzheimer's disease had more gingipains in their brain tissue.

The pharmaceutical company, which is focused on developing therapeutics to alter the course of Alzheimer's disease, funded the research.

In October 2018, Cortexyme announced results from its Phase 1b clinical trial of COR388 at the 11th Clinical Trials in Alzheimer's Disease Conference.

Alzheimer's is caused by gene expression changes that happen later in life, but little is known about how they occur.

Next steps for the test include replicating the results in sporadic Alzheimer's disease patients, who are older and often have other health issues. Later this year the firm will launch a larger trial of the drug, looking for P. gingivalis in spinal fluid, and cognitive improvements, before and after.

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