Jan 28 2019
"Drugs targeting the bacteria's toxic proteins have so far only shown benefit in mice, yet with no new dementia treatments in over 15 years it's important that we test as many approaches as possible to tackle diseases like Alzheimer's", he said in a statement.
Researchers at Shiley-Marcos Alzheimer's Disease Research Center, part of the University of California San Diego School of Medicine, found that autopsies of patients diagnosed with AD when they were alive-and confirmed by autopsy-indicate several cognitive issues symptomatic of the condition are less noticeable in living Latino patients.
Following this, scientists tested drugs in mice aimed at blocking the toxic proteins and found they were able to halt degeneration in the brain.
Other research has looked at whether various bacterial, viral, or fungal infections may play a role in Alzheimer's, but there is now not enough evidence to say. Now, a new research effort is pointing to a link between Alzheimer's and something you might not expect: gum disease.
It's possible that news of the possible link will lead to people spending more time on their dental health than they now do, though: One study found less than one third of Americans floss daily.
In separate experiments with mice, oral infection with the pathogen led to brain colonisation by the bacteria, together with increased production of amyloid beta (Aβ), the sticky proteins commonly associated with Alzheimer's.
Their NFL protein levels were measured through a blood test, brain images, and cognitive tests every 2.5 years, over the last seven.
Democratic Sen. Kamala Harris Says She Will Run for President in 2020
Kamala Harris (D-Calif.) listens during a Senate Judiciary Committee hearing on homeland security on January 16, 2018. Richard Odeja and representative John Delaney have also declared, but there is no clear front-runner as yet.
North Korea not listed as ‘enemy’ in Seoul protection report
Observers say similar incidents could occur frequently as South Korea's liberal government pushes for deeper exchanges with North Korea.
Kenya: Nairobi terrorists killed while 14 left dead
The Kenya Red Cross said it was helping families searching for loved ones missing since the attack began. Among those killed in Kenya was Luke Potter, who worked for global development charity Gatsby.
To study whether the spread of tau tangles is affected by sleep, the researchers seeded the hippocampi of mice with tiny clumps of tau and then kept the animals awake for long periods each day. Although it is not known whether getting adequate sleep will protect against AD, it won't hurt and this along with other data suggests it may even help to delay disease process if it has begun, says Holtzman.
According to a new study, bleeding gums and sensitive teeth are not only painful and annoying, but they are also having a never-before-seen connection with the Alzheimer's Disease. What the team discovered was reported January 24 in the journal Science, in an article titled, "The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans".
"The impact of infectious agents previously associated with the development and progression of Alzheimer's disease, but a causal relationship is still inconclusive". They tested the tissue samples for the presence of 2 protein fragments produced by P. gingivalis bacteria, called gingipains to see if people with Alzheimer's disease had more gingipains in their brain tissue.
The pharmaceutical company, which is focused on developing therapeutics to alter the course of Alzheimer's disease, funded the research.
In October 2018, Cortexyme announced results from its Phase 1b clinical trial of COR388 at the 11th Clinical Trials in Alzheimer's Disease Conference.
Next steps for the test include replicating the results in sporadic Alzheimer's disease patients, who are older and often have other health issues. Later this year the firm will launch a larger trial of the drug, looking for P. gingivalis in spinal fluid, and cognitive improvements, before and after.
Jan 27 2019
Facebook to Integrate the Messaging Functions of Messenger, Instagram and WhatsApp
Zuckerberg floated the idea for months and began to promote it to employees more heavily toward the end of 2018", NYT reports. That could make it easier for Facebook to track users' activities across its family of apps and target ads more effectively.
Jan 23 2019
Australian Open: Rafael Nadal, Petra Kvitova through to semifinals
He's been reluctant to go into detail about a recent tweak he made to his serve, saying it's "nothing drastic, nothing dramatic". As usual, Tiafoe was animated and talkative Tuesday. "Take as long as you want, Rafa", shouted one fan.
Jan 23 2019
Kamala Harris Announces 2020 Presidential Run
If elected, she would be the first woman, the first woman of Asian heritage and the first African-American woman as president. She was smart, fierce, and my first campaign staffer - and I dearly wish she was here with us for this moment.
Jan 22 2019
Patriots beat Chiefs to join Rams in Super Bowl
It was evident as the Rams stumbled through the first quarter and the Saints scored 13-unanswered points. Instead of first down on the LA nine-yard line, New Orleans was forced to kick a 31-yard field goal.
Jan 21 2019
Syria says repels Israeli air attack, Israel says downs Golan rocket
According to Syrian opposition media, approximately 10 missiles were fired at targets near the airport and in al-Kiswah. The military added that there was no damage done to the airport and no casualties on the ground.
Jan 21 2019
Microsoft wants your opinions to improve gaming on Windows 10
Potentially, we could see some unique apps for both iOS and Android that Apple and Android developers haven't made yet. Whereas smartphones running Windows 10 Mobile version 1703 like the Lumia 640 XL will only be supported till June 11.
Jan 20 2019
The legendary Speroni to play in goal
"I had one player say, he was very polite and not confrontational, 'Please when you criticise me, can you do it in private?'". Liverpool star Mo Salah hit his 50th Premier League goal in just 72 games.
Jan 17 2019
Pregnant duchess laughs after being called 'a fat lady' during charity visit
Markle is a known dog lover who had her rescue dog, Guy, by her side on the morning of her wedding to Prince Harry last May. The pet was rescued from a suspected puppy farm in October past year and is now with new owner Emma.
Jan 17 2019
Rafael Nadal ready to let rip remodelled serve at Australian Open
Another British player, Heather Watson, also lost early on day one, beaten 6-1, 6-2 by 31st-seeded Petra Martic . Nadal looked in impressive form in his first competitive match since the US Open in September.
Jan 15 2019
Suspect in kidnapping, homicides due in court
For the past couple of months the community of Barron and beyond has been praying for a safe return of 13-year-old Jayme Closs . On the night she was abducted, Jayme told police , she was asleep in her room when the family dog started barking.
Jan 28 2019Light snow showers possible this weekend — FORECAST
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Jan 22 2019Did you spot the lunar eclipse this morning?
Jan 20 2019Los Angeles Lakers' Michael Beasley attempts to enter game with wrong shorts
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Jan 16 2019Rihanna Sues Father For Jacking Fenty Brand Name
Jan 15 2019'Game of Thrones' Final Season Premiere Date Revealed
Jan 26 2019Family removed from plane after fellow passengers allegedly complained about body odor
Jan 26 2019Arsenal vs Manchester United predictions, match preview & how to live stream
Jan 21 2019Vince Wilfork Will Serve As Patriots’ Honorary Captain For AFC Title Game
Jan 19 2019The latest on the weekend storm
Jan 19 2019Giroud admits he is frustrated by limited Chelsea role
Jan 18 2019Chicago Bears lose more coaches to Denver Broncos
Jan 18 2019Steven Gerrard: I think Leeds have overstepped the mark
Jan 17 2019Giant rotating ice disk in river draws gawkers
Jan 16 2019Kim Kardashian Confirms She And Kanye West Are Expecting A Baby Boy
Jan 16 2019Trump’s attorney-general nominee pledges to shield Mueller’s Russian Federation probe
Jan 15 2019Trump Won’t Declare National Emergency to Build Border Wall
Jan 14 2019Equipment, not troops being moved out of Syria: Pentagon